Significant strides have been made in leveraging checkpoint inhibitor therapy to combat a number of cancers over the recent years. However, not all malignancies respond to these therapies, and those that do often become resistant, or are discontinued due to adverse reactions within the immune system. Now, researchers have shown that gut microbiota are one of the key factors influencing the success of immunotherapy targeting PD-L1 and PD-1 gene expression.
The insights obtained from this research could have additional applications in treating inflammatory and autoimmune diseases. For oncology, these findings are eye-opening and firms like Calidi Biotherapeutics Inc. (NYSE American: CLDI) could have several illuminating moments that…
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