TransCode Therapeutics (NASDAQ: RNAZ) a clinical-stage company developing immuno-oncology and RNA-based therapeutics for high-risk and advanced cancers, announced publication of a peer-reviewed article in Cancers reporting preclinical results for its lead therapeutic candidate, TTX-MC138, in a model of breast cancer bone metastasis. The study found that TTX-MC138 accumulated in metastatic bone lesions following systemic administration, reduced expression of microRNA-10b (“miR-10b”), increased expression of the downstream tumor-suppressor target HOXD10 and produced significant survival benefits compared with controls. Repeated dosing was well tolerated with no observed systemic toxicity. The findings further support TransCode’s approach of inhibiting miR-10b using its proprietary oligonucleotide nanotechnology and suggest potential applicability across additional metastatic disease settings.
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About TransCode Therapeutics
TransCode Therapeutics is a clinical stage company pioneering immuno-oncology and RNA therapeutic treatments for high risk and advanced cancers. The company’s lead therapeutic candidate, TTX-MC138, is focused on treating metastatic tumors that overexpress microRNA-10b, a unique, well-documented biomarker of metastasis. In addition, TransCode has a portfolio of other first-in-class therapeutic candidates designed to mobilize the immune system to recognize and destroy cancer cells.
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